Understanding organ development is one of biology’s most fascinating questions. A new preprint “Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium” addresses this for the ovary, using single-cell RNA sequencing to map how different cell types emerge and connecting findings that previous studies had examined separately.
This study provides a concise overview of fetal ovary development from the coelomic epithelium using single‑cell gene‑expression data, in agreement with prior reports.
Earlier studies often followed single lineages with classical readouts, whereas this work integrates single‑cell profiles across ovarian somatic compartments to outline coordinated trajectories.
Supporting‑cell precursors (future pre‑granulosa) arise from the coelomic epithelium, and supporting‑like cells adjacent to the mesonephros contribute to rete‑associated/medullary domains. The coelomic epithelium primarily seeds cortical granulosa cells, while supporting‑like cells populate medullary granulosa.
Steroidogenic stromal lineages derive from early coelomic‑epithelium progenitors.
From E12.5–E14.5, the coelomic epithelium shows biased potential toward both supporting and stromal fates; by E16.5, its potential is largely restricted to supporting fates.
These findings indicate spatial and temporal control of lineage allocation during ovarian somatic differentiation.
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